ExIR analyzes feature behavior within inferred association networks to classify and rank molecular features into four distinct biological roles — without requiring any external annotations or prior knowledge.
Features with the highest impact on biological process or disease progression. They have high centrality in the association network and significant differential expression.
Features with the highest sensitivity to different conditions and severity. They show strong differential expression but may have lower network centrality.
Features that are differentially expressed in a fluctuating manner, playing mediatory roles between drivers in the association network.
Features that are not differentially expressed but have associations with and play mediatory roles between drivers in the network.
fcor()influential package